Schedule ConsultationTPE Research Index. Clinical evidence and plain-language explainers, compiled by the Avinity Health medical team. All reviews cite primary peer-reviewed sources.
TPE Research, Statistics & Costs →Therapeutic Plasma Exchange Research
A curated index of clinical evidence, peer-reviewed studies, and plain-language explainers on TPE — compiled by the medical team at Avinity Health.
See How TPE Is Offered at Avinity →Start Here
Five resources, from a comprehensive clinical reference to a plain-language patient guide and focused reviews of emerging evidence — each maintained by the Avinity Health medical team.
Therapeutic Plasma Exchange (TPE): Research, Statistics, Costs & Clinical Data
A comprehensive clinical reference synthesizing two decades of published research — from the early parabiosis studies through the AMBAR trial and recent biological-aging work. It covers the procedure's mechanism, ASFA evidence tiers, application areas, candidacy criteria, protocol comparisons, and cost ranges, with full citations to primary sources. The most detailed resource in the index.
Read the Full TPE Clinical Reference →Plasma Exchange Explained in Plain English
A patient-facing guide that explains what therapeutic plasma exchange is, why removing and replacing plasma may produce measurable biological changes, and what the research does and does not yet establish — all without medical jargon. It also walks through the procedure experience, costs, candidacy, and the often-confused distinction between TPE, plasmapheresis, and plasma donation.
Read the Plain-English TPE Guide →Can Therapeutic Plasma Exchange Reduce Microplastics? What the First Human Study Actually Found
A clinical review of the first peer-reviewed study (Weinstein et al., 2026) to measure whether TPE reduces circulating microplastics in human patients. It explains why the procedure produced a clear reduction only in patients with high baseline levels, how the plastic apheresis equipment itself can add particles at lower levels, and why baseline testing matters before drawing conclusions about benefit.
Read the Microplastics Study Review →Is TPE Safe for Older Patients?
A clinical review of the first study (Coirier et al., 2026) to specifically test TPE tolerability at a 75+ age threshold. Adverse event rates were statistically comparable to younger patients despite significantly higher comorbidity burden — with important caveats about the hospital-based population studied.
Read the Elderly Safety Research →Therapeutic Plasma Exchange and Alzheimer's Disease: What the Research Shows
A complete review of the evidence for plasma exchange with albumin replacement in Alzheimer's disease — the proposed mechanisms, the AMBAR randomized trial and its neuroimaging and inflammatory-biomarker sub-studies, 2025 real-world outcomes, the safety record, and an honest side-by-side comparison with lecanemab and donanemab. Includes a full limitations section.
Read the Alzheimer's Evidence Review →What to Know Before You Book
The research above informs our approach — these two resources cover what it's actually like to receive PlasmaRestore™ at Avinity Health.
How Much Does Therapeutic Plasma Exchange Cost?
What actually drives the price of a TPE session — how much plasma is exchanged and whether it was calculated for your body, nurse staffing against ASFA standards, albumin concentration, and lab work — plus the questions to ask any clinic before you book, and Avinity's published protocol pricing.
See What Drives TPE Cost →What It's Like to Receive TPE at Avinity Health
A first-person walkthrough of the treatment experience — what to expect during your visit, how the procedure feels, and what recovery looks like in the days after.
Read the TPE Patient Experience →The research compiled here reflects the clinical foundation behind PlasmaRestore™, Avinity Health's physician-guided Therapeutic Plasma Exchange program. Our medical team reviews and contextualizes emerging evidence to help patients make informed decisions.
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See how Therapeutic Plasma Exchange is delivered at Avinity Health, or book a consultation with our physician-led team in Scottsdale.