Therapeutic Plasma Exchange in Scottsdale

Individual PlasmaRestore™ treatments range from $5,995 to $14,995 depending on the percentage of your calculated plasma volume exchanged, and membership pricing begins at $4,500 per treatment. Every package and membership price is published in full on ourTPE pricing and packages page, and our cost guide explains how much therapeutic plasma exchange costs— plasma volume, nurse staffing, albumin, and lab work — plus the questions to ask any clinic before you book.

TPE is a medical procedure that filters your blood by separating plasma from blood cells. The plasma containing inflammatory proteins, immune factors, and circulating debris is removed and replaced with albumin. It is delivered at Avinity Health through the PlasmaRestore™ Protocol under physician oversight.

In hospital medicine, plasma exchange is an established treatment for specific autoimmune and neurological conditions such as myasthenia gravis, Guillain-Barré syndrome, and certain blood disorders. In a longevity and optimization context, patients pursue TPE for chronic inflammation, biological aging markers, brain health and memory, immune regulation, cardiovascular and cholesterol health, post-viral recovery, and toxin and microplastic burden. Which applications are appropriate for you is a clinical decision made at your consultation. For the studies behind each application, see our TPE research hub.

Essential exchanges approximately 50% of your calculated plasma volume in about two hours. Complete exchanges 100% of it in two to four hours. Advanced exchanges 150% — 1.5× your calculated plasma volume — in a single extended session of approximately three to six hours, which raises clearance of plasma-resident substances from roughly 63% for a single-volume exchange to approximately 75–80%. Advanced is a physician-recommended option for specific clinical situations, not a default. All three are calculated from your body weight and hematocrit rather than a flat liter count, and all three are delivered to the same clinical standards — two nurses, protocol design by our board-certified nephrologist, pre-procedure lab review, post-session IV support, and ASFA monitoring. The difference is intent: Essential is built for wellness optimization, maintenance, and first-time TPE patients; Complete is the foundation of our initial reset series and intensive protocols, and remains our standard recommendation.

Advanced is a 1.5× calculated plasma volume exchange — our maximum-clearance protocol. Clearance of plasma-resident substances isn't linear with volume: a single-volume exchange clears roughly 63%, and extending to 1.5 volumes raises that to approximately 75–80%. Advanced is not our default recommendation — Complete remains the standard for most protocols. Advanced is a physician-recommended option for specific situations where a higher clearance target is clinically appropriate: higher circulating burden, or protocols where your physician determines the additional clearance justifies the longer session and larger albumin volume. It's a consultation decision, not a menu upsell.

Essential is a calculated protocol, not a flat-volume shortcut — the exchange is derived from your body weight and hematocrit, so a patient of any size receives the same proportional exchange. It is designed for wellness optimization and maintenance goals, and research suggests reducing circulating plasma burden may support those aims. For intensive therapeutic protocols — brain health, post-viral recovery, autoimmune optimization, or a higher toxic burden — Complete remains our recommendation, and your consultation is where that call gets made honestly.

Yes. Start with Essential. If you move to a Complete or Advanced series within 30 days, 100% of your first Essential treatment is credited toward it.

Because most of what a plasma exchange costs doesn't scale with volume. Staffing, the apheresis equipment, physician oversight, and the majority of the disposables are fixed regardless of how much plasma is exchanged. The same logic runs the other direction — it's why Advanced costs less than 1.5× Complete. We price the procedure, not the liters.

Most patients begin with a series of 3–6 treatments, based on protocol. Initial series are typically built on Complete; many patients then move to an Essential Maintenance Membership (six treatments, roughly every other month) or Annual Membership (twelve treatments, monthly) to hold results. Advanced series are structured individually by our physician. The exact number depends on your health goals, current status, and how you respond to treatment. This is determined during your consultation and reviewed as treatment progresses.

A PlasmaRestore™ Essential treatment takes approximately 2 hours. A Complete treatment takes approximately 2–4 hours, and an Advanced treatment approximately 3–6 hours, depending on your plasma volume and the specific protocol. During this time, blood is continuously circulated through the apheresis machine. Post-session IV support is included in every PlasmaRestore™ protocol to support recovery before you leave the clinic.

Avinity Health operates as a direct-pay clinic. TPE in a longevity or optimization context is not covered by insurance. Every package and membership price is published in full on our pricing and packages page, and our cost guide breaks down what's included and the questions to ask any clinic — both are linked from the pricing section above.

Therapeutic plasma exchange has a well-established safety profile and has been performed in hospital and clinical settings for decades. Common side effects are mild and may include temporary lightheadedness or fatigue following the session. At Avinity, every session is overseen by trained RNs with a physician consultant available throughout. All candidates are medically screened before treatment begins.

Good candidates for therapeutic plasma exchange are generally healthy adults focused on longevity, chronic inflammation reduction, cognitive health, cardiovascular optimization, or post-viral recovery. Candidates should be in stable overall health, since the procedure involves exchanging a calculated portion of your plasma volume over a 2 to 6 hour session. Candidacy is confirmed during your consultation, where your health history, current medications, and baseline lab work are reviewed by our medical team before any treatment is scheduled.

The terms are often used interchangeably. Plasmapheresis refers to the process of separating and removing plasma from the blood. Therapeutic Plasma Exchange (TPE) is the clinical application of that process — where the removed plasma is replaced with appropriate fluids (typically albumin) as part of a structured treatment protocol. At Avinity Health, TPE is delivered through the PlasmaRestore™ Protocol with guidance from an apheresis physician consultant with more than 20 years of therapeutic plasma exchange experience.

Removed plasma is replaced with clean replacement fluid — typically 5% albumin — as part of the exchange.

For most outpatient PlasmaRestore™ patients, access is through a standard IV line in each arm placed by the nursing team — no surgical catheter. One line connects to the apheresis machine; the other is a smaller line used to give calcium during the session. Access is assessed at your consultation.

Yes — you’re reclined and awake for the full session, and most patients watch TV or use their phone. After the two needle sticks that get you set up, you mostly don’t feel the exchange itself. Some patients notice brief tingling in the lips or fingers from the citrate anticoagulant, which the team addresses easily; the main challenge is sitting still.

Many patients can, but for a first session it’s smart to arrange a ride until you know how you personally respond.