A physician-directed blood filtration treatment delivered through Avinity's proprietary PlasmaRestore™ Protocol, with guidance from a therapeutic apheresis physician consultant with more than 20 years of clinical experience.
Free consultation · No commitment required · Serving Scottsdale, Phoenix & Arizona
PlasmaRestore™ Protocol
This process directly changes what is circulating in your bloodstream.
Therapeutic Plasma Exchange (TPE) — also referred to as plasmapheresis — is a medical procedure that filters your blood. Your blood is circulated through a specialized machine that separates plasma from blood cells. A portion of that plasma — containing inflammatory proteins, immune factors, toxins, and circulating debris — is removed and replaced with clean fluids (albumin).
At Avinity Health, plasma exchange therapy is delivered through the proprietary PlasmaRestore™ TPE Protocol, which integrates physician oversight, structured treatment delivery, and post-treatment monitoring.
Medical Officer
A Mayo Clinic-trained nephrologist with more than 20 years of clinical experience in therapeutic plasma exchange and apheresis-based therapies, Dr. Thomas continues to lecture at Mayo Clinic and has dedicated his career to the clinical application of plasma-based treatments.
His specialist expertise directly shapes the medical protocols and oversight behind Avinity's PlasmaRestore™ program — bringing a standard of clinical rigor to outpatient plasma exchange that is rarely available outside a major academic medical center.
What it addresses
The PlasmaRestore™ protocol is designed by our medical team for individuals who approach their health with intent and seek a more considered, physician-led model of care. It is suited to those looking for structured, personalized, and medically grounded ways to improve their health.
These are individuals who pay attention to how they feel day to day, and are open to established treatments applied with clinical judgement and evolving insight to support how they function.
Book a consultationTreatment Applications
By removing and replacing plasma, TPE creates measurable effects across immunity, inflammation, and systemic function. Below are the primary applications Avinity's physician-directed program addresses.
Chronic inflammation drives a wide range of conditions affecting how you feel and function. The PlasmaRestore™ protocol is structured around reducing circulating inflammatory proteins and tracking progress through lab monitoring at each stage of treatment.
Age-associated proteins and inflammatory factors accumulate in plasma over time and are linked to accelerated biological aging. The PlasmaRestore™ longevity protocol is designed for individuals who want a physician-directed, clinically grounded approach to addressing that burden.
The AMBAR trial demonstrated that plasma exchange may slow cognitive and functional decline in Alzheimer's disease, with separate research examining its potential role in reducing neuroinflammation. At Avinity Health, brain health protocols are evaluated individually and structured around what the current evidence supports.
The Benefits
Therapeutic Plasma Exchange works by directly altering the composition of your plasma — the component of blood responsible for carrying inflammatory signals, immune factors, lipids, and circulating proteins.
Published clinical research has demonstrated measurable effects across multiple areas:
Removes plasma containing inflammatory substances. May help reduce overall inflammation and support a healthier, more balanced immune environment.
Research has shown measurable changes in markers linked to biological aging after a series of TPE treatments.
Clinical trials, including research in Alzheimer's disease, have shown that plasma exchange may slow cognitive and functional decline.
Can reduce certain circulating cholesterol particles and lipids linked to cardiovascular risk.
Can remove specific antibodies and immune-related proteins, which may help stabilize immune response patterns.
Your blood carries toxins, inflammatory proteins, and metabolic waste that accumulate over time. TPE removes a portion of this plasma, potentially reducing that overall burden.
Why choose Avinity for TPE
At Avinity Health, plasma exchange is delivered through the PlasmaRestore™ Protocol, shaped by over 20 years of clinical experience in apheresis-based therapies. This experience informs how each treatment is assessed, performed, and supported.
The protocol is designed around the full treatment journey — from initial evaluation to post-treatment recovery — not just the procedure itself. Plasma exchange is carried out with the discipline of a hospital-based procedure within a private clinical setting, allowing for a more focused, personalized experience.
For individuals seeking Therapeutic Plasma Exchange in Scottsdale, Phoenix, or Paradise Valley, this approach offers greater clinical clarity, structure, and attention at every stage.
Read a personal account of a real Avinity Health client's experience →
What makes us different
Supported by an apheresis physician consultant with more than20 years of TPE experience
PlasmaRestore™ Protocol: individualized planning from evaluation through post-session monitoring
Treatment individualized to your body — not a standard protocol applied to every patient regardless of size or health status
Post-treatment IV support and recovery monitoring included in every protocol
Advanced therapeutic apheresis technology in a private clinical setting
Pricing
PlasmaRestore™ protocols are $9,000 per session in a 4-session protocol and $8,000 per session in a 6-session protocol. Pricing for other protocol lengths is provided at consultation.
TPE pricing varies because not every clinic is performing the same level of procedure. A lower advertised price may not mean a better deal; it may mean a smaller exchange, fewer included services, or less clinical oversight.
The full pricing page explains what is included, what affects cost, and the questions to ask before comparing any TPE or plasmapheresis clinic.
Therapeutic plasma exchange pricing breakdown & questions to ask clinics
Every PlasmaRestore™ Session Includes
Calculated for your body weight and hematocrit — not a flat liter count
One dedicated solely to you for the full 2–4 hours, one managing everything else
20+ years of experience in apheresis and renal medicine overseeing every protocol
TPE is a medical procedure that filters your blood by separating plasma from blood cells. The plasma containing inflammatory proteins, immune factors, and circulating debris is removed and replaced with albumin. It is delivered at Avinity Health through the PlasmaRestore™ Protocol under physician oversight.
Most patients undergo a series of 3–6 sessions, based on protocol. The exact number depends on your health goals, current status, and how you respond to treatment. This is determined during your consultation and reviewed as treatment progresses.
Each therapeutic plasma exchange session takes approximately 2–4 hours, depending on your plasma volume and the specific protocol. During this time, blood is continuously circulated through the apheresis machine. Post-session IV support is included in every PlasmaRestore™ protocol to support recovery before you leave the clinic.
Avinity Health operates as a direct-pay clinic. TPE in a longevity or optimization context is not covered by insurance. Full pricing information is provided during your consultation. For a detailed breakdown of what's included and questions to ask any clinic, see our therapeutic plasma exchange pricing page.
Therapeutic plasma exchange has a well-established safety profile and has been performed in hospital and clinical settings for decades. Common side effects are mild and may include temporary lightheadedness or fatigue following the session. At Avinity, every session is overseen by trained RNs with a physician consultant available throughout. All candidates are medically screened before treatment begins.
Candidacy is determined during your consultation. TPE may be appropriate for adults focused on longevity, inflammation reduction, cognitive health, or cardiovascular health. Your health history, current medications, and lab work are reviewed before treatment begins.
The terms are often used interchangeably. Plasmapheresis refers to the process of separating and removing plasma from the blood. Therapeutic Plasma Exchange (TPE) is the clinical application of that process — where the removed plasma is replaced with appropriate fluids (typically albumin) as part of a structured treatment protocol. At Avinity Health, TPE is delivered through the PlasmaRestore™ Protocol with guidance from an apheresis physician consultant with more than 20 years of therapeutic plasma exchange experience.
Service Areas
Avinity Health is located at 11000 N. Scottsdale Road, Suite 100 — accessible from Paradise Valley, Phoenix, Gainey Ranch, McCormick Ranch, and the broader metro area. Patients seeking therapeutic plasma exchange in Arizona come to Avinity Health for the PlasmaRestore™ Protocol: a physician-directed TPE program overseen by a board-certified nephrologist with over 20 years of apheresis experience.
Whether you're searching for TPE near Paradise Valley, therapeutic plasma exchange in Phoenix, or plasmapheresis in Scottsdale, the starting point at Avinity Health is the same: a clinical consultation to confirm candidacy, a structured protocol designed around your physiology, and a care team that remains involved across every session.
Our Location
11000 N. Scottsdale Road
Suite 100, Scottsdale, AZ
Mon–Fri 9:00 AM – 5:00 PM
Sat 9:00 AM – 12:00 PM
Sun Closed
Call Us
480-264-6175
The next step is a consultation where we review your health history, talk through your goals, and determine whether Therapeutic Plasma Exchange is a good fit for you. This visit is simply an opportunity to get clear, straightforward answers and understand your options.
